A Murine Interleukin-4 Antagonistic Mutant Protein Completely Inhibits Interleukin-4-induced Cell Proliferation, Differentiation, and Signal Transduction
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چکیده
منابع مشابه
Human Interleukin-4 Inhibits Proliferation of Megakaryocyte Progenitor Cells
We studied the effects of recombinant human interleukin4 (rhlL-4) on megakaryocyte colony formation from enriched hematopoietic progenitors. IL-4 strongly inhibited pure and mixed megakaryocyte colony formation in a dose-dependent manner. Formation of erythroid bursts, eosinophil colonies, and erythrocyte-containing mixed colonies was not affected by the addition of IL-4 as reported previously ...
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Address for Correspondence : Hironobu Asao, Department of Immunology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan Extensive studies on the IL-2 and IL-2 receptor system have established fundamental principles of immune responses and signal transducing mechanisms of hematopoietic cell proliferation and survival. IL-2Rb and IL-2Rg chains are associated with ...
متن کاملInterleukin 4 inhibits the proliferation but not the differentiation of activated human B cells in response to interleukin 2
The combined effect of IL-4 and IL-2 on proliferation of anti-IgM antibody or Staphylococcus aureus strain Cowan I (SAC)-preactivated B cells was investigated. It was observed that in most cases, rIL-2 used at optimal concentration induced higher levels of tritiated thymidine ([3H]TdR) uptake than rIL-4 used at optimal concentration. When rIL-4 and rIL-2 were added together, it was repeatedly f...
متن کاملAn interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13- induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors
Interleukin 4 (IL-4) and IL-13 share many biological functions. Both cytokines promote growth of activated human B cells and induce naive human surface immunoglobulin D+ (sIgD+) B cells to produce IgG4 and IgE. Here we show that a mutant form of human IL-4, in which the tyrosine residue at position 124 is replaced by aspartic acid (hIL-4.Y124D), specifically blocks IL-4 and IL-13-induced prolif...
متن کاملAn Interleukin 4 (II,-4) Mutant Protein Inhibits both IL-4 or II.-13-induced Human Immunoglobulin G4 (IgG4) and IgE Synthesis and B Cell Proliferation: Support for a Common Component Shared by II,-4 and IL-13 Receptors
L-4 directs mouse and human B cells to produce, respectively, IgG1 and IgE or IgG4 and IgE (1-6) . Recently, we (7) and others (8) cloned and expressed another T cellderived cytokine (IL-13) . As with IL-4, IL-13 induces human B cells to switch to IgG4 and IgE production in an IL-4independent fashion (7-9, 10) . IL-13 shares many other properties with IL-4 . Like IL-4, it has growth-promoting e...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.3.1480